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US 5,169,933 AGranted
Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
AssigneeNeoRx Corporation
InventorsDavid C. Anderson, A. Charles Morgan, Jr., Paul G. Abrams, Alan R. Fritzberg, Everett J. Nichols
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Abstract
Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.
Claims15
A covalently-linked complex (CLC) for targeting a defined population of cells, comprising:
- a targeting protein;
- a cytotoxic agent;
- and
- an enhancing moiety, wherein the enhancing moiety promotes CLC-target cell interaction and exhibits alpha helical structure at acidic pH and substantially unfolds at physiological pH and exhibits little or no tertiary structure.
1 more element
Dependencies are inferred from the claim text.