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US 5,169,851 AGranted
Rapamycin analog as immunosuppressants and antifungals
AssigneeAmerican Home Products Corporation
InventorsPhilip F. Hughes, John H. Musser
Life of this patent
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Abstract
Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosupressant, antifungal, and antiinflammatory activities.
Claims1
A method of treating fungal infections in mammals by administering thereto an effective amount of a compound having the formula ##STR5## or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.