Buoyant controlled release powder formulation
AssigneeE. R. Squibb & Sons, Inc.
InventorsAndrew Dennis, Peter Timmins, Kevin Lee
Life of this patent
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Abstract
A buoyant controlled release pharmaceutical powder formulation is provided which may be filled into capsules and releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alginic acid, such as sodium alginate, up to about 35% by weight of a pH-independent hydrocarbon gelling agent having a viscosity of up to about 100,000 centipoises in 2% solution at 20.degree. C. and excipients.
Claims23
A buoyant controlled release pharmaceutical formulation in the form of a powder filled capsule from which a pharmaceutical of a basic character is released at a controlled rate irrespective of the pH of the environment, comprising a pharmaceutical of a basic character, a pH-dependent polymer which is a water-soluble salt of a polyuronic acid, in an amount of up to about 45% by weight of the formulation;
- a pH-independent hydrocolloid gelling agent having a viscosity of from about 50 to about 100,000 centipoises in 2% solution at 20.degree. C., in an amount within the range of up to about 35% by weight of the formulation, and binder, said formulation being free of calcium on and carbon dioxide producing material and will float in gastric juices and which will have drug release properties similar to a tablet of similar composition.
In a controlled release pharmaceutical formulation from which a pharmaceutical of a basic character is released at a controlled rate irrespective of the pH of the environment, which includes a pharmaceutical of a basic character;
- a pH-dependent polymer which is a water-soluble salt of a polyuronic acid, in an amount of up to about 45% by weight of the formulation;
- a pH-independent hydrocolliod gelling agent having a viscosity within the range of from about 50 to about 100,000 centipoises in 2% solution at 20.degree. C., in an amount of up to about 35% by weight of the formulation;
- and binder, said formulation being free of calcium ion and carbon dioxide producing material, the improvement which comprises the said formulation being in the form of a free-flowing powder filled capsule which is buoyant so that it will float in gastric juices and will have drug release properties similar to a tablet of similar composition.
Dependencies are inferred from the claim text.