Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide
AssigneeFormulogics, Inc.
InventorsAlexander D. Lindsay, Barry A. Omilinsky
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Abstract
Environmentally-acceptable intimate mixtures of active ingredients and excipients which meet economic performance levels are prepared without use of harmful solvents by solubilizing and mixing the components in liquid carbon dioxide maintained under pressure and then slowly reducing the pressure to convert the carbon dioxide to the gaseous phase and venting the gaseous carbon dioxide.
Claims22
A method for the preparation of a water-soluble or water-dispersible formulation comprising an intimate mixture of at least one biologically active ingredient and at least one excipient, said biologically active ingredient and said excipient being soluble in liquid carbon dioxide, which comprises solubilizing and mixing said active ingredient(s) and said excipient(s) in liquid carbon dioxide under a pressure sufficient to maintain said carbon dioxide in the liquid state, reducing said pressure to convert said carbon dioxide to the gaseous state and removing said gaseous carbon dioxide to provide an intimate mixture of said water-soluble, or water-dispersible formulation.
Dependencies are inferred from the claim text.