Sulfonamide derivatives
AssigneeOno Pharmaceutical Co., Ltd.
InventorsYoshinobu Arai, Nobuyuki Hamanaka, Tohru Miyazaki
Life of this patent
Estimating the term…
Abstract
A sulfonamide derivative of the general formula: Tx--R.sup.1 (I) wherein, R.sup.1 represents (i) COOR.sup.11, (ii) CH.sub.2 OR.sup.12 or (iii) CONR.sup.13 R.sup.14, Tx--represents ##STR1## X.sub.b represents (i) bond, (ii) alkylene group of from 1 to 4 carbon atoms or (iii) alkenylene group of from 2 to 4 carbon atoms (with the proviso that --CH.dbd.CHCH.sub.2 -- and --CH.sub.2 CH.dbd.CHCH.sub.2 -- are excluded), R.sup.2b represents (i) hydrogen atom, (ii) halogen atom or (iii) alkyl group of from 1 to 4 carbon atom(s), posses an antagonistic activity on TXA.sub.2.
Claims6
A sulfonamide derivative of the formula:
- ##STR183## wherein R.sup.1 represents (i) COOR.sup.11,
- (ii) CH.sub.2 OR.sup.12 or
- (iii) CONR.sup.13 R.sup.14,
- wherein R.sup.11 represents a hydrogen atom, alkyl group of from 1 to 20 carbon atom(s), mono-, bi- or tri-aromatic carbocyclic ring(s) containing not more than 15 carbon atoms which may be partially or fully saturated, wherein the said carbocyclic ring(s) is unsubstituted or substituted by an alkyl or alkoxy group of from 1 to 4 carbon atom(s) or halogen atom, or cholesterol,
- R.sup.12 represents a hydrogen atom or COR.sup.15,
- R.sup.13 and R.sup.14 each represent a hydrogen atom or alkyl group of from 1 to 4 carbon atom(s) or NR.sup.13 R.sup.14 represents an amino acid residue selected from glycine, alanine, valine, isoleucine, leucine, serin, threonine, proline, asparagine, glutamine, methionine, phenylalanine, tyrosine, aspartic acid, glutamic acid or lysine or a heterocyclic ring selected from the group consisting of pyrrole, imidazole, pyrazole, pyrroline, pyrrolidine and imidazolidine, or
- R.sup.15 represents an alkyl group of from 1 to 4 carbon atom(s) or phenyl group, ##STR184## X.sub.b represents (i) bond,
- (ii) alkylene group of from 1 to 4 carbon atoms or
- (iii) alkenylene group of from 2 to 4 carbon atoms (with the proviso that --CH.dbd.CHCH.sub.2 -- and --CH.sub.2 CH.dbd.CHCH.sub.2 -- are excluded),
- R.sup.2b represents
- (i) hydrogen atom,
- (ii) halogen atom or
- (iii) alkyl group of from 1 to 4 carbon atom(s), the configuration of a double bond between C.sub.5 and C.sub.6 in the formula (B) is cis,
- cyclodextrin clathrates thereof, or non-toxic salts thereof in the case that R.sup.11 represents a hydrogen atom or NR.sup.13 R.sup.14 represents an amino acid residue selected from glycine, alanine, valine, isoleucine, leucine, serin, threonine, proline, asparagine, glutamine, methionine, phenylalanine, tyrosine, aspartic acid, glutamic acid or lysine.
Dependencies are inferred from the claim text.