Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
AssigneeMallinckrodt Medical, Inc.
InventorMartin Wenzel
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Abstract
The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an inactive carrier and/or one or more auxiliary substances, wherein the hydrogen containing compound comprises at least one deuterium atom. The invention further relates to a compound to be used for said composition and to a kit for preparing a radio-diagnostic composition.
Claims11
A radiodiagnostic or radiotherapeutic composition, comprising a radiolabelled hydrogen containing compound which has been labelled with a diagnostic or therapeutic radionuclide, and a pharmaceutically acceptable liquid, wherein the radiolabelled hydrogen containing compound includes at least one deuterium atom.
A kit for preparing a radiodiagnostic composition comprising:
- a non-radiolabelled deuterated compound selected from the group consisting of deuterated N-alkylaminoalkylaryl compounds, deuterated metallocenyl compounds, deuterated fatty acids, deuterated carbohydrates, deuterated proteins or proteinaceous substances, deuterated peptides selected from the group consisting of amino acids, di-, tri- or polypeptides, deuterated alkyleneamine oximes, substituted or unsubstituted deuterated alkyl isocyanides, and deuterated oximes, said non-radiolabelled deuterated compound being capable of reacting with a radiolabelling agent selected from the group consisting of water soluble compounds of a radioactive halogen, metal-radionuclide salts, and chelates of metal-radionuclides, wherein the metal radionuclide is selected from the group consisting of Tc-99m, Pb-203, Ga-67, Ga-68, As-72, In-111, In-113m, Ru-95, and Ru-97,
- one or more formulation agents to which a solution of the desired radionuclide should be added, and
- instructions for reacting the non-radiolabelled deuterated compound with the radiolabelling agent.
Dependencies are inferred from the claim text.