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US 5,166,317 AGranted
Neurotrophic factor
AssigneeHouston Biotechnology Incorporated
InventorsThomas L. Wallace, David E. Potter, Craig E. Crosson
Life of this patent
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Abstract
Novel neutrotrophic factor compositions are provided, obtained from lung tissue. The factors are found to be active on parasympathetic ganglion neutrons enhancing acetylcholine activity. The compositions find use in the treatment of a number of eye disorders.
Claims8
A composition comprising a neurotropic factor characterized by:
- an ED.sub.50 of at least about 25 ng/ml as measured in vitro using embryonic day 8 chicken ciliary neurons;
- a pl in the range of 5.6-7.0;
- a molecular weight as determined by SDS gel electrophoresis of
- obtainable from mammalian lung tissue;
- capable of maintaining viable embryonic ciliary neurons in vitro, as compared to the absence of said composition;
- capable of increasing choline acetylatransferase activity in parasympathetic ciliary neurons in culture, wherein said increasing is reponsive to changes in potassium ion concentration;
- and does not bind heparin.
4 more elements
Dependencies are inferred from the claim text.