Use of relaxin in cardiovascular therapy
AssigneeGenentech, Inc.
InventorsMichael Cronin, Phyllis L. Osheroff, David G. Ward
Life of this patent
Estimating the term…
Abstract
The invention concerns the use of relaxin in the cardiovascular therapy, and specifically in the treatment of acute and chronic heart failure.
Claims23
A method for increasing cardiac output by administering to a patient exhibiting pathologically diminished cardiac output a therapeutically effective amount of a compound capable of specific binding to a relaxin receptor in the atrium of the heart and increasing the force or rate of atrial contraction.
A method of treating heart failure by administering to a patient in need of such treatment a therapeutically effective amount of a compound capable of specific binding to a relaxin receptor in the atrium of the heart and increasing the force or rate of atrial contraction.
A method of stimulating cardiac inotropy and chronotropy, comprising administering to a patient in need of such stimulation a therapeutically effective amount of a compound capable of specific binding to a relaxin receptor in the atrium of the heart and increasing the force or rate of atrial contraction.
A method of restoring cardiac function following acute heart failure comprising intravenously administering to a patient in need of such treatment a liquid pharmaceutical formulation comprising a compound capable of specific binding to a relaxin receptor in the atrium of the heart, in an amount capable of restoring myocardial contractility to a predepression level.
Dependencies are inferred from the claim text.