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AssigneeNitto Denko Corporation
InventorsYasuo Kihara, Kenjiro Mori, Tetsuo Watanabe, Takashi Tsuji
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A latex for immobilization of a physiologically active substance is prepared by copolymerizing a monomer mixture comprising: (a) 100 parts by weight of an aromatic vinyl monome4r; (b) 0.01 to 5 parts by weight of a vinyl monomer having a sulfonic acid group; (c) 1 to 20 parts by weight of an .alpha.,.beta.-unsaturated carboxylic acid monomer; and (d) 0.05 to 5 parts by weight of a polyfunctional monomer for internal cross-linking; in water using a water-soluble radical polymerization initiator in the absence of an emulsifying agent. An antigen or antibody or a hapten can be covalently bound to particles of the latex to form a reagent for use in immuno nephelometry.
A latex for immobilization of a physiologically active substance comprising copolymer particles having an average particle diameter of 0.03 to 2.0 microns, said particles being prepared by copolymerizing in water using a water soluble radical polymerization initiator a monomer mixture consisting essentially of:
A latex reagent for latex immuno nephelometry, comprising a latex containing copolymer particles having an average particle diameter of 0.03 to 2.0 .mu.m, and an antigen, an antibody or haptene covalently bound to said latex, said copolymer particles prepared by copolymerizing in water using a water soluble radical polymerization initiator a monomer mixture consisting essentially of:
Dependencies are inferred from the claim text.