Anti-infective and antithrombogenic medical articles and method for their preparation
AssigneeBecton, Dickinson and Company
InventorsDonald D. Solomon, M. Parke Byron
Life of this patent
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Abstract
An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
Claims14
A method for preparing a medical article, the method comprising:
- a) preparing a blend of chlorhexidine and pellets of a base polymer having a water absorption of at least 0.6% by weight;
- b) heating said blend to a sufficient temperature within a range from about 160.degree. C. to about 250.degree. C. and for a sufficient time to form a homogeneous melt of said polymer having said chlorhexidine uniformly distributed therein;
- and
- c) extruding said melt through a die to form a medical article having said chlorhexidine bulk distributed throughout said polymer.
A method for preparing a medical article, the method comprising:
- a) preparing a homogeneous melt of a polymer having a water absorption of at least 0.6% by weight and a chlorhexidine;
- and
- b) extruding said melt at a temperature in a range from about 160.degree. C. to about 250.degree. C. through a die to form a medical article having said chlorhexidine bulk distributed throughout said polymer.
Dependencies are inferred from the claim text.