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AssigneeTerumo Kabushiki Kaisha
InventorsMasatomi Sasaki, Shinichi Kaneda, Nobuyoshi Kashiwagi
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A medical material comprising a high-molecular weight material and a heparin derivative is provided, which high-molecular weight material comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, and which heparin derivative comprises heparin and an epoxy compound having at least two epoxy groups part of which is bound to amino groups in the heparin, the amino groups not bound to the epoxy groups in said high-molecular weight material being bound to the epoxy groups not bound to the amino groups in the heparin derivative. Also provided are an intermediate (high-molecular weight material) to be used for said medical material, as well as processes for producing said medical material and said intermediate. This medical material retains the activity of heparin intact and has it bound strongly and in a large amount. Further, this medical material has good biocompatibility. The above-described intermediate and processes for production further enhance the characteristics of the above-described medical material.
A medical material which comprises a high-molecular weight material (E) and a heparin derivative (F), wherein said high-molecular weight material (E) comprises a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups, a polymer (D), different from polymer A, having at least two amino groups and an epoxy group containing polymer (B) having a vinyl monomer as an essential component;
An antithrombotic material which comprises a high-molecular weight material (E) and a heparin derivative (F), wherein said high-molecular weight material (E) comprises a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups, a polymer (D), different from polymer A, having at least two amino groups and an epoxy group containing polymer (B) having a vinyl monomer as an essential component;
A medical material obtained by reacting unreacted amino groups of a high-molecular weight material (E) with unreacted epoxy groups of a heparin derivative (F), wherein the high-molecular weight material (E) is obtained by reacting a reaction product containing unreacted epoxy groups which is obtained by reacting a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups with an epoxy group containing polymer (B) having a vinyl monomer as an essential component, with a polymer (D), different from polymer A, having at least two amino groups, and wherein said heparin derivative (F) is obtained by reacting heparin with a polymer (H) having two diglycidyl groups per one polymer chain wherein some of the epoxy groups of the polymer (H) remain unreacted.
A process for producing a medical material, which comprises reacting unreacted amino groups of a high-molecular weight material (E) with unreacted epoxy groups of a heparin derivative (F), wherein said high-molecular weight material (E) is obtained by reacting a reaction product containing unreacted epoxy groups which is obtained by reacting a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups with an epoxy group containing polymer (B) having a vinyl monomer as an essential component, with a polymer (D), different from polymer A, having at least two amino groups, and wherein said heparin derivative (F) is obtained by reacting heparin with a polymer (H) having two diglycidyl groups per one polymer chain wherein some of the epoxy groups of the polymer (H) remain unreacted.
Dependencies are inferred from the claim text.