Process for the manufacture of a directly compressible starch for use in the manufacture of tablets, and tablets obtained
AssigneeSociete D'Exploitation De Produits Pour Les Industries Chimiques Seppic
InventorsBernard Brancq, Gerard Trouve
Life of this patent
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Abstract
The present invention relates to a process for the preparation of grains of starch, which comprises granulating a mixture obtained by spraying 1 to 20%, and preferably 2 to 6% by weight, of a starch paste obtained from native starch under mild conditions, on to 99 to 80% by weight of grains of native starch, and drying, grinding and sieving the resulting product to give aggregates (grains) having a mean particle size of between 100 and about 500 .mu.m.
Claims18
A process for the preparation of granules of directly compressible starch which comprises:
- a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85.degree. C. and a heating time of about 15 to about 45 minutes;
- b) granulating between about 99% to about 80% by weight of grains of native starch with about 1 to about 20% by weight of the starch paste obtained in step a);
- and
- c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 .mu.m.
A process for the preparation of granules of directly compressible starch which comprises:
- a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85.degree. C. and a heating time of about 15 to about 45 minutes;
- b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a);
- and
- c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 .mu.m.
A process for the preparation of granules of directly compressible starch which comprises:
- a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85.degree. C. and a heating time of about 15 to about 45 minutes;
- b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a) and used at a temperature above about 60.degree. C.;
- and
- c) drying the wet mass thus obtained to a moisture content sufficient to yield granules which are directly compressible and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 .mu.m.
Novel starch granules suitable for compression into tablets, comprising starch granules prepared by the mutual adhesion of grains of native starch by means of starch paste, which have a mean particle size of between about 100 and about 500 .mu.m, which give, on compression under about 20 daN, tablets having a crushing strength of at least about 50N, and which disintegrate in water in less than about 5 minutes.
A process for the preparation of granules of directly compressible starch which comprises:
- a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85.degree. C. and a heating time of about 15 to about 45 minutes;
- b) granulating between about 99% to about 80% by weight of grains of native starch with about 1 to about 20% by weight of the starch paste obtained in step a);
- and
- c) drying the wet mass thus obtained to a residual moisture of 11-12% and grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 .mu.m.
A process for the preparation of granules of directly compressible starch which comprises:
- a) preparing a starch paste by heating gradually an aqueous dispersion of native starch at a maximum temperature not exceeding about 85.degree. C. and a heating time of about 15 to about 45 minutes;
- b) granulating between about 98% to about 96% by weight of grains of native starch with about 2 to about 4% by weight of the starch paste obtained in step a);
- and
- c) drying the wet mass thus obtained to a residual moisture of 11-12% and, grinding and sieving to yield aggregates having a mean particles size of between about 100 and about 500 .mu.m.
Dependencies are inferred from the claim text.