Obturating means for container for pharmaceutical and medical preparation
AssigneeHelvoet Pharma N.V.
InventorsAnita Thijs, Willy Van De Poel
Life of this patent
Estimating the term…
Abstract
An obturating structure and a container provided with such an obturating structure and a syringe comprising a slidable obturating structure acting as a stopper; and a process for treating an obturating structure prepared at least from one elastomeric material and intended for a static or dynamic seal of a container holding a pharmaceutical or medical preparation, in which process at least the elastomeric part of the obturating structure is at least partially subjected to a treatment with elementary halogen or chemical compound(s) containing reactive halogen.
Claims16
An obturator for sealing a container for medical or pharmaceutical preparations, said obturator formed of chloro butyl rubber wherein at least a portion of a surface of said obturator is fluorinated upon contact thereof with a fluorine-containing gas such that said fluorinated portion extends to a depth within said obturator of at least about 10 namometers, said fluorinated surface having a substantially reduced degree of reactivity with said medical and said pharmaceutical preparations in contrast to a corresponding surface which has not been fluorinated.
A method for forming an obturator adapted for sealing a container for medical or pharmaceutical preparations, which method comprises:
- forming an obturator configured and adapted for sealing a container for a medical or a pharmaceutical preparation from chloro butyl rubber;
- and
- contacting a surface portion of said obturator with a fluorine-containing gas so as to fluorinate at least a portion of said contacted surface.
- said fluorinated surface having a substantially reduced degree of reactivity with respect to said medical and said pharmaceutical preparations in contrast to a corresponding surface which has not be fluorinated.
A method for forming an obturator adapted for sealing a container for medical or pharmaceutical preparations, which method comprises:
- forming an obturator configured and adapted for sealing a container for medical or pharmaceutical preparations from chlorobutyl rubber;
- washing at least a portion of a surface of said obturator;
- drying said washed surface portion;
- and
- contacting said surface portion of said obturator with a gaseous reagent comprising from about 1 to 10% fluorine gas and 90 to 99% nitrogen under a pressure of between about 10.sup.5 and 5.times.10.sup.5 Pa. for between about 60 to 900 seconds at a temperature of between about 15.degree.-25.degree. C. so as to at least partially fluorinate said contacted surface portion to a depth of at least about 10 nanometers,
- said fluorinated surface having a substantially reduced degree of reactivity with respect to said medical and said pharmaceutical preparations in contrast to a corresponding surface which has not been fluorinated.
Dependencies are inferred from the claim text.