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US 5,160,737 AGranted
Liquid polymer composition, and method of use
AssigneesPerio Products Ltd., Yissum Research Development Company
InventorsMichael Friedman, Amnon Sintov
Life of this patent
Estimating the term…
Abstract
The invention relates to a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.
Claims18
A sustained-released liquid polymer composition which consists essentially of:
- (a) one or more sustained release acrylic polymers;
- (b) a pharmacological agent;
- (c) a release adjusting agent selected from the group consisting of a cross-linking agent, a polysaccharide, a lipid, a protein, a sodium citrate, sodium docusate, an amino acid and sodium polyphosphate;
- and
- (d) a pharmaceutically acceptable vehicle selected from the group consisting of water;
- ethyl alcohol;
- and ethyl alcohol and water,
- wherein said sustained release acrylic polymers are selected from the group consisting of:
- (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1;
- (2) a methacrylic acid type B compolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2,
- (3) a dimethylaminoethylacrylate/ethylmethacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20;
- and
- (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.
10 more elements
A sustained-released liquid polymer composition which consists essentially of:
- (a) one or more sustained release acrylic polymers;
- (b) a pharmacological agent;
- (c) a release adjusting agent selected from the group consisting of a cross-linking agent, a polysaccharide, a lipid, a protein, a sodium citrate, sodium docusate, an amino acid and sodium polyphosphate;
- (d) a pharmaceutically acceptable vehicle selected from the group consisting of water;
- ethyl alcohol;
- and ethyl alcohol and water;
- and
- (e) a plasticizer;
- wherein said sustained release acrylic polymers are selected from the group consisting of:
- (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1;
- (2) a methacrylic acid type B copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2;
- (3) a dimethylaminoethylacrylate/ethylmethacrylatecopolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20;
- and
- (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.
11 more elements
Dependencies are inferred from the claim text.