Process for the production of cyclopropanenitrile derivatives
AssigneeLonza Ltd.
InventorPaul Hanselmann
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Abstract
A process for the production of cyclopropanenitrile derivatives. A diol of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, branched or unbranched, or a C.sub.1 -C.sub.6 alkenyl group, branched or unbranched, or wherein R.sub.1 and R.sub.2 together is a C.sub.4 -C.sub.6 cycloalkyl ring, is converted with thionyl chloride to a compound of the formula: ##STR2## The latter compound is then oxidized to a compound of the formula: ##STR3## The formula IV compound is converted with a cyano compound to the end product of the formula: ##STR4##
Claims11
Process for the production of a cyclopropanenitrile derivative of the formula:
- ##STR11## wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, branched or unbranched, or a C.sub.1 -C.sub.6 alkenyl group, branched or unbranched, or wherein R.sub.1 and R.sub.2 together are a C.sub.4 -C.sub.6 cycloalkyl ring, characterized in that, in a first stage, a diol of the formula:
- ##STR12## wherein R.sub.1 and R.sub.2 have the above-mentioned meaning, is reacted with thionyl chloride to a compound of the formula:
- ##STR13## wherein R.sub.1 and R.sub.2 have the above-mentioned meaning, in the second stage, the compound of formula III is oxidized to a compound of the formula:
- ##STR14## wherein R.sub.1 and R.sub.2 have the above-mentioned meaning, and, in the third stage, the compound of formula IV is converted with a cyano compound to the cyclopropanenitrile derivative of formula I.
Dependencies are inferred from the claim text.