O.sup.17 isotopic peroxides
AssigneeAtochem
InventorsJean-Pierre Schirmann, Jean-Jacques Barieux
Life of this patent
Estimating the term…
Abstract
The peroxides which include the O.sup.17 isotope, especially the hydrogen peroxides and peroxides and hydroperoxides prepared therefrom, are well adapted as nonradioactive labeled compounds for use in the medicinal and biological arts.
Claims9
An isotopic peroxide comprising more than 0.1% by weight of O.sup.17 oxygen in the --O--O-- group thereof having one of the general formulae:
- R--O.sup.16 --O.sup.17 --R' (I)
- or
- R--O.sup.17 --O.sup.17 --R' (II)
- wherein R and R', which may be identical or different, are each a hydrogen atom;
- an R.sub.1 linear or branched chain alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy or cycloalkoxy, or aryl radical, or an inorganic, organometallic or organometalloidal group, the latter containing at least one of said R.sub.1 radicals and a metal or metalloid comprising Al, Ge, Pb, P, Li, Sn, Sb, Te, Se, As or B, with the proviso that such organometal or metalloid group may itself comprise one or more --O.sup.16 --O.sup.17 groups;
- or one of the radicals:
- ##STR5## in which R.sub.1 is as above defined and M is a hydrogen atom or an alkali metal, said radicals R.sub.1 containing up to 20 carbon atoms and optionally being substituted by one or more fluorine, chlorine or bromine atoms or --OH or --NO.sub.2 groups, with the further proviso that R and R' may together form a divalent atom or group T, such divalent group T itself comprising a wholly hydrocarbon radical or one or more --O.sup.16 --O.sup.17 -- linkages, the free valences of which being bonded to organic or inorganic moieties.
A composition comprising isotopic peroxides comprising more than 0.1% by weight of O.sup.17 oxygen in the --O--O-- group thereof having the general formula:
- R--O.sup.16 --O.sup.17 --R' (I)
- and the general formula:
- R--O.sup.17 --O.sup.17 --R' (II)
- wherein R and R' in both formula (I) and formula (II), which may be identical or different, are each a hydrogen atom;
- an R.sub.1 linear or branched chain alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy or cycloalkoxy, or aryl radical, or an inorganic, organometallic or organometalloidal group, the latter containing at least one of said R.sub.1 radicals and a metal or metalloid comprising Al, Ge, Pb, P, Li, Sn, Sb, Te, Se, As or B, with the proviso that such organometal or metalloid group may itself comprise one or more --O.sup.16 --O.sup.17 groups;
- or one of the radicals:
- ##STR6## in which R.sub.1 is as above defined and M is a hydrogen atom or an alkali metal, said radicals R.sub.1 containing up to 20 carbon atoms and optionally being substituted by one or more fluorine, chlorine or bromine atoms or --OH or --NO.sub.2 groups, with the further proviso that R and R' may together form a divalent atom or group T, such divalent group T itself comprising a wholly hydrocarbon radical or one or more --O.sup.16 --O.sup.17 -- linkages, the free valences of which being bonded to organic or inorganic moieties.
A process for the preparation of an O.sup.17 isotopic peroxide compound comprising reacting H.sub.2 O.sub.2.sup.17 or H--O.sup.17 --O.sup.16 --H with precursor reagent thereof.
Dependencies are inferred from the claim text.