Compounds

A compound of the general formula (I):

• ##STR32## or an in vivo hydrolyzable pharmaceutically acceptable ester thereof;
• or a pharmaceutically acceptable salt thereof, wherein R.sup.0 represents a phenyl or naphthyl group which is unsubstituted or substituted with up to five substituents compounding a halogen, alkyl, phenyl, alkoxy, haloalkyl, hydroxy alkyl, hydroxy, amino, nitro, carboxy and pharmaceutically acceptable salts, esters and amides thereof, alkoxycarbonyl, alkoxycarbonyl alkyl alkylcarbonyloxy, or alkylcarbonyl, group;
• or a benzofuranyl group, which is unsubstituted or substituted with an alkyl group,
• X represents a bond or --O--CH.sub.2,
• R.sup.1 represents a hydrogen atom or a moiety ##STR33## wherein R.sup.0 and X are as defined above;
• R.sup.2 and R.sup.3 independently represent a hydrogen atom or a straight or branched chain alkyl group having up to 12 carbon atoms,
• n represents an integer 1 or 2,
• Y represents a bond or a moiety --CH.sub.2 --O--, moiety A represents a phenyl or naphthyl group, R.sup.4 represents a bond or an oxygen atom or --R.sup.4A or a moiety --O--R.sup.4A --, or a moiety --R.sup.4A --O--, wherein R.sup.4A represents a C.sub.1-12 alkylene group, a C.sub.1-12 alkyenylene group or a C.sub.1-12 alkynylene group, and R.sup.5 represents a thiazolidine -2,4-dione group, which is unsubstituted or substituted by alkyl;
• hydroxy;
• alkoxy;
• oxo;
• amino;
• alkanoyl amino;
• mono- and di- alkyl amino;
• mono- and di- alkylaminoalkyl;
• fluoro, chloro, bromo;
• carboxy and pharmaceutically acceptable salts, esters and amides thereof;
• alkanoyloxy, phenyl, naphthyl, phenylalkyl, or naphthylalkyl, wherein the phenyl or naphthyl ring is optionally substituted as in variable R.sup.0.