Methylenediphosphonic acid compounds and methods of use for the treatment of rheumatism and osteophorosis
AssigneeToray Industries, Inc.
InventorsNorio Kawabe, Keijiro Takanishi, Shu Matsumoto
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Abstract
This invention relates to a methylenediphosphonic acid compound expressed by the formula (1). The compound has a marked effect as an anti-inflammatory agent or, more particularly, against inflammations accompanying disturbances in bone metabolism. ##STR1##
Claims11
A methylenediphosphonic acid compound expressed by the formula (1) ##STR22## in the formula, R.sup.1 representing a pharmacologically allowable cation, hydrogen or a straight or branched alkyl group comprising from 1 to 4 carbon atoms, R.sup.1 's being the same or different, X representing CH.sub.2 or S(CH.sub.2).sub.n (.sub.n being 0-4) and R.sup.2 representing ##STR23## (R.sup.3 representing a straight or branched alkyl group comprising from 1 to 6 carbon atoms, R.sup.3 's being the same or different and R.sup.4 representing a straight or branched alkyl group comprising from 1 to 4 carbon atoms, R.sup.4 's being the same or different).
A method of treating rheumatism comprising administering an effective amount of a methylenediphosphonic acid compound expressed by the formula (1) ##STR24## in the formula, R.sup.1 representing a pharmacologically allowable cation, hydrogen or a straight or branched alkyl group comprising from 1 to 4 carbon atoms, R.sup.1 's being the same or different, X representing CH.sub.2 or S(CH.sub.2).sub.n (.sub.n being 0-4) and R.sup.2 representing ##STR25## (R.sup.3 representing a straight or branched alkyl group comprising from 1 to 6 carbon atoms, R.sup.3 's being the same or different and R.sup.4 representing a straight or branched alkyl group comprising from 1 to 4 carbon atoms, R.sup.4 's being the same or different ).
A method of treating osteoporosis comprising administering an effective amount of a methylenediphosphonic acid compound expressed by the formula (1) ##STR29## in the formula, R.sup.1 representing a pharmacologically allowable cation, hydrogen or a straight or branched alkyl group comprising from 1 to 4 carbon atoms, R.sup.1 's being the same or different, X representing CH.sub.2 or S(CH.sub.2).sub.n (.sub.n being 0-4) and R.sup.2 representing ##STR30## (R.sup.3 representing a straight or branched alkyl group comprising from 1 to 6 carbon atoms, R.sup.3 's being the same or different and R.sup.4 representing a straight or branched alkyl group comprising from 1 to 4 carbon atoms, R.sup.4 's being the same or different).
Dependencies are inferred from the claim text.