Effect of N,N,N-trimethylsphingosine on protein kinase-C activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
AssigneeThe Biomembrane Institute
InventorsKazuko Handa, Yasuyuki Igarashi, Mahammad N. Ahmad, Sen-Itiroh Hakomori
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Abstract
The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory an anti-metastatic activity over related compounds.
Claims6
A method of modulating intercellular contact comprising exposing cells to a biologically effective amount of N,N-dimethylsphingosine or N,N,N-trimethylsphingosine wherein said biologically effective amount is an amount that inhibits the expression or function of a cell adhesion molecule.
Dependencies are inferred from the claim text.