Deuterated analogs of 1,25-dihydroxycholecalciferol
AssigneeHoffmann-La Roche Inc.
InventorsEnrico G. Baggiolini, Bernard M. Hennessy, Milan R. Uskokovic
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Abstract
The invention is directed to deuterated vitamin D analogs, and processes and intermediates for their preparation. The end products, that is the deuterated vitamin D analogs, are useful for the treatment osteoporosis and cutaneous inflammations such as psoriasis, and contact dermatitis.
Claims8
A compound of the formula ##STR27## wherein R.sub.1 and R.sub.2 are either both hydrogen or both deuterium, R.sub.3 is hydrogen or Si(Alk).sub.3, wherein Alk is lower alkyl.
A compound of the formula ##STR28## wherein R.sub.1 and R.sub.2 are either both hydrogen or both deuterium and R.sub.3 is hydrogen.
Dependencies are inferred from the claim text.