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US 5,149,820 AGranted
Deuterated compounds
AssigneeNorsk Hydro a.s.
InventorsBernt Borretzen, Rolf O. Larsen, Erik O. Pettersen, John M. Dornish, Reider Oftebro
Life of this patent
Estimating the term…
Abstract
Deuterated aromatic aldehydes of the formula: ##STR1## where Ar is substituted phenyl, and derivatives thereof represented by the formula: ##STR2## where Ar is substituted or unsubstituted phenyl, and X.sub.1 and X.sub.2 are substituted hetero atoms or together with the carbon to which they are attached form a heterocycle. These compounds are useful as anticancer and analgesic agents.
Claims1
A compound selected from the group consisting of a compound of the formula:
- ##STR9## wherein Ar is phenyl substituted by alkyl of 1-5 carbon atoms, cycloalkyl of 3-6 carbon atoms, halogen, nitro, amino, monoalkylamino of 1-5 carbon atoms or dialkylamino of 1-5 carbon atoms in each alkyl group, or is unsubstituted phenyl, which substituted or unsubstituted phenyl is non-deuterated or partly or completely deuterated, and X.sub.1 and X.sub.2 together with the carbon atom to which they are attached form a cyclic thioacetal, dithiane or oxazolidine, and a pharmaceutically acceptable salt thereof, with the proviso that when Ar is unsubstituted phenyl, then X.sub.1 and X.sub.2 cannot be dithiane.
Dependencies are inferred from the claim text.