Ecteinascidins 736 and 722
AssigneeThe Board of Trustees of the University of Illinois
InventorsKenneth Rinehart, Ryuichi Sakai
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Abstract
Ecteinascidins 722 and 736 (Et's 722 and 736) have been isolated from the Caribbean tunicate Ecteinascidia turbinata and their structures have been assigned as tetrahydro-.beta.-carboline-substituted bis(tetrahydro- isoquinolines) related to the previously reported Et's 729 and 743. Et's 722 and 736 protect mice in vivo at very low concentrations against P388 lymphoma, B16 melanoma, and Lewis lung carcinoma.
Claims3
Ecteinascidin 736, essentially free of cellular material of E. turbinata, and having the structural formula:
- ##STR3## wherein X .dbd.OH and R .dbd.CH.sub.3.
Ecteinascidin 722, essentially free of celluar material of E. turbinata, and having the structural formula:
- ##STR4## wherein X .dbd.OH and R .dbd.H.
O-Methyl-ecteinascidin 736, essentially free of cellular material of E. turbinata, and having the structural formula:
- ##STR5## wherein X .dbd.OCH.sub.3 and R .dbd.CH.sub.3.
Dependencies are inferred from the claim text.