Boronated porphyrin compounds
AssigneeThe Regents of the University of California
InventorsStephen B. Kahl, Myoung-Seo Koo
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Abstract
A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms, This invention was made with Government support under NIH Grant No. CA-37961 awarded by the Department of Health and Human Services and under the Associated Universities Inc. Contract No. De-AC02-76CH00016 with the U.S. Department of Energy. The Government has rights in this invention.
Claims7
A compound having the structure ##STR17## where R is ##STR18## R.sup.1 is --H or ##STR19## R.sup.3 is carborane, and R.sup.2 is --H, an alkyl having 1 to 7 carbon atoms or an aryl having 6 to about 7 carbon atoms, or a physiologically acceptable salt.
A compound having the structure ##STR21## where R.sup.3 is 1,2-icosahdedral closo-carborane or substituted or unsubstituted 1,7-icosahedral closo-carborane, R.sup.3 substituted or unsubstituted is enriched in boron-10 wherein the substituent is a carboxyl group and M.sup.+ is a physiologically acceptable salt.
Dependencies are inferred from the claim text.