Vaccines for human respiratory virus
AssigneeThe University of North Carolina at Chapel Hill
InventorsGail W. Wertz, Peter L. Collins
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Abstract
This invention discloses compositions of DNA and proteins that are useful for preparing vaccines against human respiratory syncytial virus [HRSV]. The DNA compositions include structural genes coding for native structural viral proteins and immunogenic fragments of these proteins. Host cells transformed with the above DNA compositions are also disclosed. Vaccines made from the native structural viral proteins or immunogenic fragments are also disclosed as well as methods for protecting humans by inoculation with these vaccines.
Claims26
A recombinant DNA molecule comprising a DNA sequence encoding human respiratory syncytial virus structural proteins selected from the group consisting of:
- a) F protein;
- b) G protein;
- c) 22K protein;
- d) 9.5K protein;
- e) major capsid protein N;
- and
- immunogenic fragments thereof.
Dependencies are inferred from the claim text.