Porous inorganic ultrasound contrast agents
AssigneeThe Du Pont Merck Pharmaceutical Company
InventorsJoseph L. Glajch, Gary L. Loomis, Walter Mahler
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Abstract
The invention relates to ultrasound contrast agents comprising porous particles of an inorganic material containing an entrapped gas or liquid and having an average particle diameter of about 0.05 to 500 microns, said inorganic material being selected from one or more of the group consisting of: monomeric or polymeric borates; monomeric or polymeric aluminas; monomeric or polymeric carbonates; monomeric or polymeric silicas; and monomeric or polymeric phosphates; and pharmaceutically acceptable organic or inorganic cationic salts thereof.
Claims60
An ultrasound contrast agent comprising a pharmaceutically acceptable carrier and porous particles of an inorganic material containing an entrapped gas and having an average particle diameter of 0.01 to 500 microns, said inorganic material being selected from one or more of the group consisting of:
- monomeric or polymeric borates;
- monomeric or polymeric aluminas;
- monomeric or polymeric carbonates and bicarbonates;
- monomeric or polymeric silicas and silicates;
- monomeric or polymeric aluminosilicates;
- and monomeric or polymeric phosphates;
- and pharmaceutically acceptable organic or inorganic cationic salts thereof.
Dependencies are inferred from the claim text.