Method and means for extending the host range of insecticidal proteins
AssigneeThe Regents of the University of California
InventorsNatarajan Sivasubramanian, Brian A. Federici
Life of this patent
Estimating the term…
Abstract
The invention relates to a method for increasing the host range or toxicity of an insecticidal protein exerting its activity via interaction with the gut epithelium of insects within its host range, by delivering the insecticidal protein to the gut epithelium of a target insect with the aid of an other, targeting protein capable of binding to the gut epithelium of the target insect. The targeting protein may, for example, be of viral origin or, alternatively, may be a bacterial protein or protein domain having high affinity for the lipid components of membranes.
Claims23
A method for increasing the host range or toxicity of an insecticidal protein or a protein domain exerting its activity via interaction with the gut epithelium of insects within its host range, comprising delivering said insecticidal protein or protein domain to the gut epithelium of a target insect with the aid of a targeting protein or protein domain capable of binding to said gut epithelium of said target insect.
A method for increasing the host range or toxicity of an insecticidal protein or a protein domain exerting its activity via interaction with the gut epithelium of insects within its host range, comprising delivering said insecticidal protein or a protein domain to the gut epithelium of a target insect with the aid of a targeting bacterial protein or protein domain having high affinity for the lipid components of membranes.
Dependencies are inferred from the claim text.