Isoprenoid phospholipase A2 inhibitors and preparations comprising same
AssigneeBristol-Myers Squibb Company
InventorsF. Ivy Carroll, Anita Lewin, Kenneth Tramposch, Stephen A. Steiner
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein R.sub.1 is CH.dbd.CY--C(CH.sub.3).dbd.CHX wherein X and Y are different and each is of the formula ##STR2## wherein R' and R" independently are H or alkyl of C.sub.1-6 and R.sub.1 includes all possible geometric isomers are demonstrated effective in treating inflammation, both topically and internally. The mechanism appears to be the inhibition of phospholipase A.sub.2 enzymes.
Claims11
A compound of the formula A ##STR11## wherein R.sub.1 is CH.dbd.CY--C(CH.sub.3).dbd.CHX wherein X and Y are different and each is of the formula ##STR12## wherein R' and R" independently are H or alkyl of C.sub.1-6 and R.sub.1 includes all possible geometric isomers.
Dependencies are inferred from the claim text.