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AssigneeOncogen
InventorsJoseph P. Brown, Charles D. Estin, Gregory D. Plowman, Timothy M. Rose, Karl E. Hellstrom, Ingegerd Hellstrom, Anthony Purchio, Shiu-Lok Hu, Sridhar Pennathur
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Peptides or proteins related to a melanoma associated antigen are described. These are produced in large quantities via recombinant DNA techniques and/or by chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulations which can induce an immune response that selectively destroys melanoma cells in a vaccinated individual. Where the peptides or proteins are expressed by a recombinant virus, inactivated or live virus vaccine formulations may be prepared.
A substantially pure, non-denatured p97 protein antigen having an amino acid sequence substantially as depicted in FIGS. 3A and 3B from amino acid residue number 21 to 738.
Dependencies are inferred from the claim text.