Peptide fragments containing HP and LP cross-links
AssigneeWashington Research Foundation
InventorDavid R. Eyre
Life of this patent
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Abstract
A method of determining collagen degradation in vivo, including quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. The method includes immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.
Claims6
A peptide having an amino acid sequence consisting essentially of ##STR14##
A peptide having an amino acid sequence consisting essentially of ##STR15##
A peptide having an amino acid sequence consisting essentially of ##STR16##
A peptide having an amino acid sequence consisting essentially of ##STR17##
A peptide having an amino acid sequence consisting essentially of ##STR18##
A peptide having an amino acid sequence consisting essentially of ##STR19##
Dependencies are inferred from the claim text.