# US 5,139,743 A · Biochemical analysis apparatus

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- Number: US 5,139,743 A
- Document ID: US5139743A
- Status: Granted
- Kind: A
- Application number: 07/526,960
- Filed: 1990-05-22
- Granted: 1992-08-18
- Earliest claimed: 1987-09-24
- Assignees: Fuji Photo Film Co., Ltd.
- Inventors: Hideo Ishizaka; Yoshio Saito
- Web page: https://patentgrep.com/patent/US5139743A

## CPC

- G01N 35/00663: {of consumables}
- G01N 33/48764: {Test tape taken off a spool}
- G01N 35/00009: {provided with a sample supporting tape, e.g. with absorbent zones}
- G01N 35/1083: {with one horizontal degree of freedom}
- G01N 2035/00019: {cassette structures}
- G01N 2035/00039: {Transport arrangements specific to flat sample substrates, e.g. pusher blade}
- G01N 2035/00435: {Refrigerated reagent storage}
- G01N 2035/00445: {Other cooling arrangements}
- G01N 2035/00455: {Controlling humidity in analyser}
- G01N 2035/00673: {of reagents}
- G01N 2035/00752: {bar codes}
- G01N 2035/0441: {for samples}
- G01N 2035/1025: {Fluid level sensing}
- Y10T 436/110833: Utilizing a moving indicator strip or tape
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A biochemical analysis apparatus comprises a sample accommodating region, an accommodating region for a test film reacting with a liquid sample to give rise to a change, and a conveyor for sequentially pulling out the test film from the test film accommodating region. An applicator takes up the liquid sample from the sample accommodating region and applies it to the test film at the position to which the test film has been pulled out. An incubator incubates the sample-applied film portion for a predetermined time, and a measuring device measures the change at the sample-applied film portion during or after the passage of the predetermined time. Both the incubator and the measuring device are provided at the position where the sample application onto the test film is carried out by the sample application means.

## Claims

### Claim 1

A biochemical analysis apparatus comprising:
i) a sample accommodating means for accommodating a liquid sample,
ii) an elongated test film capable of reacting with a liquid sample to give rise to a change, said elongated test film having an unused portion which is wound up in a film feed cassette;
iii) a non-movable test film accommodating means for accommodating said unused portion of said elongated test film which is wound up in said film feed cassette, said non-moveable test film accommodating means comprising a refrigerator for maintaining said unused portion of said elongated test film at a predetermined low temperature;
iv) a test film conveyance means for sequentially conveying said unused portion of said elongated test film accommodated in said non-moveable test film accommodating means out of said non-moveable test film accommodating means and to a predetermined position outside of said non-moveable test film accommodating means;
v) a sample application means for taking up said liquid sample from said sample accommodating means and applying a predetermined amount of said liquid sample onto said unused portion of said elongated test film at said predetermined position;
vi) an incubator for maintaining the sample-applied portion of said elongated test film at a predetermined temperature for a predetermined time;
vii) a measurement means for measuring a change at said sample-applied portion of said elongated test film during or after the passage of said predetermined time, and
viii) a test film discarding region separate from said non-moveable test film accommodating means, such that said test film conveyance means conveys the sample-applied portion of said elongated test film from said predetermined position into said test film discarding region and takes out a predetermined length of said unused portion of said elongated test film so as to be positioned at said predetermined position,
wherein both said incubator and said measurement means are provided at the position where the sample application onto said elongated test film is carried out by said sample application means,
wherein said test film discarding region includes a film wind-up cassette for winding up the sample-applied portion of said elongated test film, and
wherein said film feed cassette and wind-up cassette are separate and distinct from each other, such that said predetermined position is located between said film feed cassette and said film wind-up cassette; and
further wherein said non-movable test film accommodating means accommodates a plurality of elongated test films wound up in a plurality of corresponding film feed cassettes disposed in parallel with one another, said plurality of elongated test films being arranged in side by side relationship in a lateral direction so that side edges of adjacent elongated test films face each other.

### Claim 2 (depends on 1)

The apparatus as defined in claim 1, wherein said refrigerator includes a dehumidifying device for maintaining said unused portion of said elongated test film at a predetermined humidity.