Rapamycin analogs as immunosuppressants and antifungals

Abstract

Reduction of C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities.

Dependencies are inferred from the claim text.