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US 5,138,045 AGranted
Polyamine conjugated oligonucleotides
AssigneeIsis Pharmaceuticals, Inc.
InventorsPhilip D. Cook, Charles J. Guinosso
Life of this patent
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Abstract
Oligonucleotide analogs are provided having improved cellular uptake and improved nuclease resistance. Modification of oligonucleotides through the attachment of nitrogenous moieties, especially polyamines, hydrazines and the like to nucleosidic portions of the analogs is disclosed. Oligonucleotides targeted at the tat region of HIV comprise certain preferred embodiments.
Claims11
An oligonucleotide analog having at least one nucleoside modified by direct attachment of a polyamine at the 5' site of its sugar moiety.
Dependencies are inferred from the claim text.