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US 5,137,901 AGranted
Substituted aminomethyltetralins and their heterocyclic analogues
AssigneeBayer Aktiengesellschaft
InventorsBodo Junge, Rudolf Schohe, Peter-Rudolf Seidel, Thomas Glaser, Jorg Traber, Ulrich Benz, Teunis Schuurman, Jean-Marie V. De Vry
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Abstract
For binding 5-HT.sub.1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.
Claims13
A substituted aminomethylchroman of the formula ##STR171## in which Y denotes a straight-chain or branched, saturated or unsaturated alkylene chain having up to 6 carbon atoms,
- Z denotes a group of the formula ##STR172## w denotes 0, 1 or 2, p denotes 1 or 2,
- R.sup.1 denotes hydrogen, lower alkyl or benzyl or
- denotes the group --(Y.sup.1 -Z.sup.1), where Y.sup.1 or Z.sup.1 may be identical or different to Y and Z have the abovementioned meaning of Y and Z,
- E and F are identical or different and
- denote hydrogen, lower alkyl or lower alkoxy or
- denote fluorine, chlorine, bromine, cyano or
- denote a group of the formula --CONH.sub.2, or
- E and F together form a phenyl or cyclohexane ring, or a salt thereof.
5 more elements
Dependencies are inferred from the claim text.