Process for preparing a neutralized oxidized cellulose product and its method of use
AssigneeJohnson & Johnson Medical, Inc.
InventorsLowell Saferstein, Stephen Wolf, Lola Kamp, Cary Linsky, David Wiseman
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AssigneeJohnson & Johnson Medical, Inc.
InventorsLowell Saferstein, Stephen Wolf, Lola Kamp, Cary Linsky, David Wiseman
Estimating the term…
Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.
A process for preparing a storage stable, non-irritating and therapeutic neutralized oxidized cellulose product comprising the steps of:
Dependencies are inferred from the claim text.