Pyrazole derivatives, and pharmaceutical composition comprising the same

A compound of the formula:

• ##STR5## wherein R.sup.1 is aryl which may be substituted with substituent(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)amino;
• or a pyridyl group;
• R.sup.2 is methyl substituted with amino, lower alkylamino, halogen or acyloxy;
• acyl;
• cyano;
• halogen;
• lower alkylthio;
• lower alkylsulfinyl;
• or a tetrazolyl group;
• and
• R.sup.3 is aryl substituted with lower alkyl, lower alkylthio, lower alkylsulfinyl, halogen, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, lower alkoxy, cyano, hydroxy or acyl;
• or a thienyl group which may be substituted with lower alkylthio, lower alkysulfinyl or lower alkylsulfonyl;
• provided that
• when R.sup.2 is carboxy, esterified carboxy or tri(halo)methyl,
• then R.sup.3 is aryl substituted with lower alkylthio, lower alkylsulfinyl, amino, lower alkylamino, acylamino, lower alkyl(acyl)amino, hydroxy or acyl;
• or a thienyl group substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, or
• R.sup.1 is aryl substituted with substituent(s) selected from the group consisting of lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, hydroxy, lower alkylsulfonyloxy, nitro, amino, lower alkylamino, acylamino and lower alkyl(acyl)amino;
• or a pyridyl group or pharmaceutically acceptable salt thereof.