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US 5,132,313 AGranted
Non-competitive NMDA receptor antagonists and methods for their use
AssigneeUniversity of Pittsburgh
InventorsAlan P. Kozikowski, Yuan-Ping Pang
Life of this patent
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Abstract
The present invention relates to novel NMDA receptor antagonists and methods for their use. The present invention also provided pharmaceutical compositions comprising such NMDA receptor antagonists.
Claims16
A compound represented by formula I:
- ##STR5## wherein:
- X.sub.1 is selected from the group consisting of [H,] OH, NH.sub.2, SH, N.dbd.C.dbd.S and OCH.sub.3 ;
- X.sub.2 is selected from the group consisting of H, OH, NH.sub.2, SH, N.dbd.C.dbd.S and OCH.sub.3 ;
- R.sup.1 is selected from the group consisting of H and a C.sub.1 -C.sub.4 linear or branched alkyl group;
- R.sup.2 is selected from the group consisting of H and a C.sub.1 -C.sub.4 linear or branched alkyl group;
- or R.sup.1 and R.sup.2 can be joined to form a pyrrolidine ring or a piperidine ring;
- represents a saturated or unsaturated bond;
- or pharmaceutically acceptable salts thereof;
- with the proviso that:
- (1 ) said compound is in the cis-fused form;
- and
- (2 ) said compound is in the enantiomer of R stereochemistry at the amine bearing carbon atom substantially free of any other stereoisomer.
9 more elements
A compound represented by formula I:
- ##STR6## wherein:
- X.sub.1 is selected from the group consisting of H, OH, NH.sub.2, SH, N.dbd.C.dbd.S and OCH.sub.3 ;
- X.sub.2 is selected from the group consisting of OH, NH.sub.2, SH, N.dbd.C.dbd.S and OCH.sub.3 ;
- R.sup.1 is selected from the group consisting of H and a C.sub.1 -C.sub.4 linear or branched alkyl group;
- R.sup.2 is selected from the group consisting of H and a C.sub.1 -C.sub.4 linear or branched alkyl group;
- or R.sup.1 and R.sup.2 can be joined to form a pyrrolidine ring or a piperidine ring;
- represents a saturated or unsaturated bond;
- or pharmaceutically acceptable salts thereof;
- with the proviso that:
- (1) said compound is in the cis-fused form;
- and
- (2) said compound is in the enantiomer of R stereochemistry at the amine bearing carbon atom substantially free of any other stereoisomer.
9 more elements
Dependencies are inferred from the claim text.