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US 5,130,439 AGranted
Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
OwnerYoung S. Lo, Lucius T. Rossanoinventors
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Abstract
Novel tetrazolylphenylboronic acids, methods for their preparation, and their use in the syntheses of angiotensin II receptor antagonists are disclosed.
Claims6
A compound of formula I ##STR14## wherein:
- P is triphenylmethyl, tertiary-butyl, C.sub.1 -C.sub.4 alkoxymethyl, methylthiomethyl, phenyl C.sub.1 -C.sub.4 alkoxymethyl, p-methoxybenzyl, 2,4,6-trimethylbenzyl, 2-(trimethylsilyl)ethyl, tetrahydropyranyl, piperonyl, or benzenesulfonyl;
- and
- R.sup.1a and R.sup.1b are each independently chlorine, bromine, C.sub.1 -C.sub.4 alkoxy or hydroxy;
- and
- R.sup.1a and R.sup.1b can be taken together with B to form a cyclic structure ##STR15## where A is phenyl, or (CH.sub.2).sub.n, where n is 2-4.
2 more elements
Dependencies are inferred from the claim text.