US 5,130,335 A · Tetralin esters of phenols or benzoic acids having retinoid like activity

Abstract

Retinoid-like activity is exhibited by compounds of the formula ##STR1## where the R groups are independently hydrogen, or lower alkyl; A is --C(O)O--, --OC(O)--, --C(O)S--, or --SC(O)--; n is 0-5; and Z is H, --COB where B is --OH or a pharmaceutically acceptable salt, or B is --OR.sub.1 where R.sub.1 is an ester-forming group, or B is --N(R).sub.2 where R is hydrogen or lower alkyl, or Z is --OE where E is hydrogen or an ether-forming group or --COR.sub.2 where R.sub.2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is --CHO or an acetal derivative thereof, or Z is --COR.sub.3 where R.sub.3 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4 and the sum of n and m does not exceed 4.

Claims17

Dependent claims

A compound of the formula ##STR9## where the R groups are independently hydrogen, or lower alkyl;

n is 0-5;
and Z is --COB where B is --OH or a pharamaceutically acceptable salt, or B is --OR.sub.1 where R.sub.1 is an ester-forming group, or B is --N(R).sub.2 where R is independently hydrogen or lower alkyl, or Z is OE where E is hydrogen or COR.sub.2 where R.sub.2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is --CHO or an acetal derivative thereof, or Z is COR.sub.3 where R.sub.3 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4 and the sum of n and m does not exceed 4.

Dependencies are inferred from the claim text.

Facts

Application

07/558,737Filed 27 Jul 1990 · continuation

Priority

11 Apr 1988

Granted

14 Jul 1992

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07C 69/86
Of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic…
A61P 17/00
Drugs for dermatological disorders
A61P 27/02
Drugs for disorders of the senses: ophthalmic agents
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents

Abstract

Claims17

Dependent claims

A compound of the formula ##STR9## where the R groups are independently hydrogen, or lower alkyl;

n is 0-5;
and Z is --COB where B is --OH or a pharamaceutically acceptable salt, or B is --OR.sub.1 where R.sub.1 is an ester-forming group, or B is --N(R).sub.2 where R is independently hydrogen or lower alkyl, or Z is OE where E is hydrogen or COR.sub.2 where R.sub.2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is --CHO or an acetal derivative thereof, or Z is COR.sub.3 where R.sub.3 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4 and the sum of n and m does not exceed 4.

Dependencies are inferred from the claim text.

Tetralin esters of phenols or benzoic acids having retinoid like activity

Life of this patent

Abstract

Claims17

Tetralin esters of phenols or benzoic acids having retinoid like activity

Life of this patent

Abstract

Claims17