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US 5,129,905 AGranted
Methods for in situ prepared calcium phosphate minerals
AssigneeNorian Corporation
InventorBrent R. Constantz
Life of this patent
Estimating the term…
Abstract
Calcium phosphate minerals are formed by using phosphoric acid source substantially free of uncombined water in conjunction with a calcium source, normally as any combination of carbonate, phosphate and hydroxide, and, as required, any additional base to neutralize the phosphoric acid. Protein may be optionally added. The resulting product is readily formed and then sets to a hard, stable, workable shaped object.
Claims16
A method for making calcium phosphate minerals comprising:
- combining a partially neutralized phosphoric acid source substantially free of uncombined water, wherein said partial neutralization is not more than about neutralization of the first proton of phosphoric acid, which is then combined with a calcium source, and neutralizing anions including at least one of carbonate, phosphate and hydroxide in an amount sufficient to substantially neutralise said phosphoric acid source, and a physiologically acceptable lubricant in an amount to provide a kneadable mixture;
- agitating the mixture to produce a substantially uniform mixture;
- and
- allowing the substantially uniform mixture to set and become annealed to a hard workable structure.
1 more element
A method for making hydroxyapatite comprising:
- combining calcium phosphate monobasic or its monohydrate, a neutralizing source comprising at least one of calcium carbonate, alkali metal hydroxide, calcium hydroxide or a calcium phosphate, in an amount to provide a substantially neutral product, and an aqueous lubricant in an amount to provide a kneadable mixture;
- agitating the mixture to produce a substantially uniform mixture;
- and
- allowing the substantially uniform mixture to set and become matured to a hard workable structure.
1 more element
Dependencies are inferred from the claim text.