Oxazinone substituted phosphines
AssigneeBiofor, Ltd.
InventorSung J. Lee
Life of this patent
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Abstract
A new class of phosphines in which the phosphorous atom is bonded directly to the carbon of an oxazinone: ##STR1## In addition to their anti-inflammatory activity, these phosphines are useful as intermediates in producing compounds where the phosphine is replaced by a benzylidine, compounds which have also been proven useful in the treatment of inflammation and other conditions associated with arthritis.
Claims12
A compound of the formula:
- ##STR23## wherein:
- R is a member selected from the group consisting of lower alkyl, mononuclear cycloalkyl of from about 3-7 carbon atoms, mononuclear aryl and binuclear aryl;
- R.sup.2 --R.sup.6 are the same or different and represent a member selected from the group consisting of hydrogen, lower alkyl, lower alkenyl and lower cycloalkyl;
- and
- X.sup.- is a halide.
(Dihydro-N-methyl-2H-1,2-oxazin-3(4H)-oxo-4-yl)-triphenylphosphonium bromide.
A pharmaceutical composition wherein the active ingredient is a compound of the formula:
- ##STR24## wherein:
- R is a member selected from the group consisting of lower alkyl, mononuclear cycloalkyl of from about 3-7 carbon atoms, mononuclear aryl and binuclear aryl;
- R.sup.2 -R.sup.6 are the same or different and represent a member selected from the group consisting of hydrogen, lower alkyl, lower alkenyl and lower cycloalkyl;
- and
- X.sup.- is a halide;
- and a pharmaceutically acceptable carrier.
A method for treating inflammation in a mammal which comprises administering a safe and effective amount of a compound having the formula:
- ##STR25## wherein:
- R is a member selected from the group consisting of lower alkyl, mononuclear cycloalkyl of from about 3-7 carbon atoms, mononuclear aryl and binuclear aryl;
- R.sup.2 -R.sup.6 are the same or different and represent a member selected from the group consisting of hydrogen, lower alkyl, lower alkenyl and lower cycloalkyl;
- and
- X.sup.- is a halide.
Dependencies are inferred from the claim text.