PDGF analogs and methods of use
AssigneeZymoGenetics, Inc.
InventorsMark J. Murray, James D. Kelly
Life of this patent
Estimating the term…
Abstract
Proteins having substantially the same biological activity as PDGF are provided. In one aspect, a protein homodimer having two polypeptide chains is disclosed, each of the chains being a mosaic of amino acid sequences substantially identical to portions of the A- and B-chains of PDGF, the protein being chemotactic or mitogenic for fibroblasts. Therapeutic compositions comprising such proteins in combination with a physiologically acceptable carrier or diluent are also provided. Such therapeutic compositions may be used within methods for enhancing the wound-healing process in warm-blooded animals.
Claims24
A substantially pure protein homodimer having substantially identical to the A-chain of PDGF, as shown in FIGS. 3H or 3I.
A protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts.
A therapeutic composition comprising a protein homodimer having two polypeptide chains, each of said chains being substantially identical to the A-chain of PDGF, as shown in FIGS. 3H or 3I, and a physiologically acceptable carrier.
A therapeutic composition comprising a protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts, and a physiologically acceptable carrier.
A method for enhancing the wound-healing process in a warm-blooded animal, comprising administering to the animal a therapeutically effective amount of a composition comprising a protein homodimer having two polypeptide chains, each of said chains being substantially identical to the A-chain of PDGF, as shown in FIGS. 3H or 3I, and a physiologically acceptable carrier.
A method for enhancing the wound-healing process in warm-blooded animals, comprising administering to the animal a therapeutically effective amount of a composition comprising a protein homodimer having two polypeptide chains, each of said chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, said protein being chemotactic or mitogenic for fibroblasts, and a physiologically acceptable carrier.
A method for enhancing the wound-healing process in warm-blooded animals, comprising administering to the animal a therapeutically effective amount of a composition comprising a protein homodimer having two polypeptide chains, each of said chains being substantially identical to either the A-chain or B-chain of PDGF, said protein being chemotactic or mitogenic for fibroblasts, and a physiologically acceptable carrier.
Dependencies are inferred from the claim text.