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US 5,128,145 AGranted
Dosage form for Parkinson's disease, spasticity and muscle spasms
AssigneeAlza Corporation
InventorsDavid E. Edgren, Gurdish K. Bhatti, Howard A. Carpenter
Life of this patent
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Abstract
A dosage form is disclosed comprising a drug and a maltodextrin polymer for administering to a patient a drug in need of therapy.
Claims4
A dosage form for delivering a drug to a drug receptor, wherein the dosage form comprises:
- (a) a wall comprising at least in part a composition permeable to the passage of fluid, which wall surrounds:
- (b) a compartment;
- (c) at least one exit port in the wall that connects the exterior of the dosage form with the compartment;
- (d) a dispensing composition in the compartment comprising a maltodextrin comprising a 500 to 1,000,000 molecular weight and a degree of polymerization of 3 to 6,140;
- (e) 1 mg to 750 mg of drug in the dispensing composition for delivering the drug, by the combined operations of (a) and (b), through the exit port from the dosage form;
- and,
- (f) a push composition in the compartment comprising a hydrogel and an osmotically effective solute, which composition in the presence of fluid that enters the compartment increases in volume and thereby pushes the dispensing composition from the dosage form.
4 more elements
An improvement in an osmotic dosage form for delivering a drug to a patient, wherein the osmotic dosage form comprises:
- (a) a wall comprising a composition permeable to the passage of fluid, which wall surrounds:
- (b) a compartment;
- (c) at least one passageway in the wall that connects the exterior of the osmotic dosage form with the compartment;
- (d) a composition in the compartment that increases its volume in the presence of fluid that enters the compartment;
- (e) a dose of a drug in the compartment;
- (f) a dose of a drug in contact with the exterior of the osmotic dosage form;
- and wherein the improvement comprises:
- (g) a maltodextrin in the compartment comprising a 500 to 1,000,000 molecular weight and a degree of polymerization of 3 to 6,140, which maltodextrin is compatible with the drug and aids in delivering the drug through the passageway from the osmotic dosage form.
5 more elements
Dependencies are inferred from the claim text.