Virus vaccine
AssigneeThe Upjohn Company
InventorsLeonard E. Post, Darrell R. Thomsen
Life of this patent
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Abstract
Provided are a virus vaccine, comprising a properly incapacitated virus lacking an antigen of the wild-type virus which is useful for serologically distinguished between vaccinated and infected animals, methods for distinguishing between vaccinated and infected animals and multivalent vaccines.
Claims10
A vaccine comprising a non-naturally occurring pseudorabies virus, characterized in that upon replication it produces no glycoprotein X (gX) as a result of the viral DNA being altered or deleted.
A multivalent vaccine comprising a properly incapacitated pseudorabies virus having inserted within the gene encoding glycoprotein X, a DNA sequence encoding a heterologous polypeptide capable of raising an immune response.
Dependencies are inferred from the claim text.