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US 5,126,145 AGranted
Controlled release tablet containing water soluble medicament
OwnerKenneth L. Evenstad, Kuldip R. Malhotra +1inventors
InventorsKenneth L. Evenstad, Kuldip R. Malhotra, Victoria A. O'Neill
Life of this patent
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Abstract
A sustained or controlled release tablet is disclosed. The tablet comprises a water soluble medicament, a hydroxypropyl methylcellulose having sustaining action, a pharmaceutical binding agent, and a hydrophobic component.
Claims24
A controlled release uncoated tablet comprising:
- (a) about 5-20 percent by weight hydroxypropyl methylcellulose having a viscosity of about 1000 or greater, a substitution rate for the methoxyl group of about 7-30% and a substitution rate for the hydroxypropoxyl group of about 7-20%;
- (b) about 2-8 percent by weight hydroxypropyl methylcellulose having a viscosity of less than about 1000, methyl cellulose, or polyvinyl pyrollidone;
- (c) about 5-15 percent by weight hydrogenated vegetable oil or stearic acid;
- and
- (d) a therapeutically active material having a water solubility of about 0.1-30% at normal room temperature;
- wherein said tablet has a dissolution profile, with a substantially zero order absorption characteristic, of about 10-35% within 2 hours after ingestion.
3 more elements
A controlled release uncoated tablet comprising:
- (a) about 5-30 percent by weight hydroxypropyl methylcellulose with sustaining properties;
- (b) about 2-15 percent by weight water soluble pharmaceutical binder;
- (c) about 2-20 percent by weight hydrophobic component;
- and
- (d) a medicament having a solubility of about 0.1 to 30 wt-% in water;
- wherein said tablet has a dissolution profile, with a substantially zero order absorption characteristic, of about 10-35% within 2 hours after ingestion.
3 more elements
Dependencies are inferred from the claim text.