Process for preparing phenethanol ethers by the reduction of corresponding phenylglyoxal acetals
AssigneeHoechst Celanese Corporation
InventorsJohn R. Durrwachter, Michael Meier, Graham N. Mott, Werner H. Mueller
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Abstract
Substituted phenethanol ethers are prepared by the catalytic reduction of corresponding substituted phenylglyoxal acetals. The catalytic reduction is carried out by reacting a substituted phenylglyoxal acetal with hydrogen in the presence of an acid catalyst and a metal catalyst. Certain substituted phenylglyoxal acetals, and more particularly, 4-hydroxyphenylglyoxal dialkyl acetals are prepared by reacting 4-hydroxyacetophenone with a primary or a secondary alkyl alcohol in the presence of a hydrogen ion (H+) source and a nitrosonium ion (NO+) source.
Claims12
A method of preparing a substituted phenethanol ether, comprising the step of reducing a corresponding substituted phenylglyoxal acetal by reacting said acetal with hydrogen in the presence of an acid catalyst and a metal catalyst.
A method of preparing a phenethanol ether of the formula ##STR12## comprising the step of reacting a phenylglyoxal acetal of the formula ##STR13## with hydrogen is the presence of a metal hydrogenation catalyst and a acid catalyst wherein R.sub.1 is a primary or a secondary alkyl group and R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6, are independently hydrogen, an alkyl group, an unsubstituted aryl group, a substituted aryl group, a hydroxy group, an alkoxy group, an unsubstituted or a substituted aryloxy group, a halogen, a carboxylic acid group, a carboxylic acid derivative group, an acyloxy group, an aroyloxy group, an amino group, an alkyl substituted amino group, a substituted or an unsubstituted aryl substituted amino group.
Dependencies are inferred from the claim text.