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US 5,124,334 AGranted
Benzylalcohol phospholipase A.sub.2 inhibitors
AssigneeThe Du Pont Merck Pharmaceutical Company
InventorWendell W. Wilkerson
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Abstract
The invention relates to benylalcohol phospholipase A.sub.2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A.sub.2 -mediated conditions in mammals by administration of a therapeutically effective amount of such a benzylalcohol phospholipase A.sub.2 inhibitor.
Claims32
A substituted benzylalcohol phospholipase A.sub.2 inhibitor of the formula:
- ##STR62## or a pharmaceutically acceptable salt thereof, wherein Ar is ##STR63## and Z is H, F, Cl, Br, --OR.sup.1, or --S(O).sub.m R.sup.1, where R.sup.1 is H, methyl, or ethyl, and m is 0, 1, or 2;
- n is 2 or 3;
- X is NH or O;
- and
- R is C.sub.7 -C.sub.25 alkyl, pyridyl, or
- R is benzhydryl, phenyl-(4-pyridyl)methyl, C.sub.7 -C.sub.25 alkaryl or substituted alkaryl where the substitution is on the aromatic moiety and is F, Cl, Br, --OR.sup.3, --S(O).sub.r R.sup.3, or C.sub.1 -C.sub.10 alkyl, where
- R.sup.3 is methyl or ethyl, and r is 0, 1, or 2;
- provided that when X is O, n must be 3.
5 more elements
Dependencies are inferred from the claim text.