Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
AssigneeAmerican Cyanamid Company
InventorLawrence Ritter
Life of this patent
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Abstract
Stable, cosmetically acceptable gel formulations of the tetracycline antibiotics for the topical treatment of acne in humans. Minocycline hydrochloride is the preferred antibiotic and the pharmaceutical vehicle is a volatile silicone solvent in combination with an emollient ester cosolvent and a polyethylene gelling agent.
Claims22
A stable, cosmetically elegant gel formulation for the topical treatment of acne in humans comprising an effective amount of a compound selected from the group consisting of those of the formulae:
- ##STR2## where R is hydrogen or methyl, R.sub.1 is hydrogen or hydroxyl, and R.sub.2, R.sub.3 and R.sub.4 are hydrogen, mono(lower alkyl)amino or di(lower alkyl)amino with the proviso that R.sub.2, R.sub.3 and R.sub.4 cannot all be hydrogen or the non-toxic addition salts or hydrates thereof at a concentration of 0.10% to 10.0% w/w in a pharmaceutical vehicle comprising:
- (a) about 1.0% to 40.o% w/w of a gelling agent comprised of:
- (i) a polyethylene homopolymer;
- or
- (ii) a polyethylene/vinyl acetate copolymer;
- or
- (iii) a polyethylene/acrylic acid copolymer;
- or
- (iv) any combination thereof;
- (b) about 5.0% to 75% w/w of an emollient ester cosolvent;
- and
- (c) about 20.0% to 70% w/w of a volatile silicone solvent.
A composition according to claim in which the tetracycline antibiotic is 7-dimethylamino-6-deoxy-6-demethyltetracycline as its hydrochloride salt which is known as minocycline hydrochloride.
Dependencies are inferred from the claim text.