US 5,116,756 A · Process for producing FK-506

Abstract

Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

Claims1

Dependent claims

A biologically pure culture of the microorganism, Streptomyces sp., ATCC No. 55098.

Dependencies are inferred from the claim text.

Facts

Application

07/646,555Filed 28 Jan 1991

Granted

26 May 1992

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C12N 1/205
Bacteria; Culture media therefor: bacterial isolates
C12P 17/188
Containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin: heterocyclic…
C12P 19/445
Preparation of O-glycosides, e.g. glucosides: the saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
C12R 2001/465
Bacteria or Actinomycetales ; using bacteria or Actinomycetales: streptomyces

Process for producing FK-506

Life of this patent

Abstract

Claims1

Process for producing FK-506

Life of this patent

Abstract

Claims1