Diagnosis and treatment of insulin dependent diabetes mellitus
AssigneeYeda Research and Development Co. Ltd.
InventorsIrun R. Cohen, Dana Elias, Doron Markovits
Life of this patent
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Abstract
A 65 KD heat shock protein, proteins cross-reactive therewith, or antibodies thereto can be used for detecting in humans the existence of, a tendency to develop, or the initiation of a process leading to insulin dependent diabetes mellitus. Antibodies to hsp65 can be used to detect the hsp65 molecule in blood or urine. The hsp65 molecule of any species, or any other substance immunologically cross-reactive therewith, when administered with a tolerogenic carrier, can be used for the prevention or treatment of IDDM prior to development of clinical symptoms thereof.
Claims7
A method for diagnosing the presence or incipience of IDDM in a patient showing no blatant signs or symptoms of arthritis, comprising testing said patient for the presence of hHSP65 protein or anti-hHSP65 antibodies, whereby a result indicating the positive presence of hHSP65 proteins or anti-hHSP65 antibodies indicates a high probability of the presence or incipience of IDDM.
A method for diagnosing for the presence or incipience of IDDM in a patient showing no blatant signs or symptoms of arthritis, comprising testing said patient for an antibody or T-cell which immunoreacts with hHSP65 or any protein which immunoreacts with an antibody against hHSP65, whereby a result indicating the positive presence of an antibody or T-cell which immunoreacts with hHSP65, or any protein which immunoreacts with an antibody against hHSP65 indicates a high probability of the presence of incipience of IDDM.
Dependencies are inferred from the claim text.