Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants
AssigneeCase Western Reserve University
InventorRoger E. Marchant
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Abstract
The present invention is directed to a process for synthesizing hydroxylated plasma-polymerized films, as well as the hydroxylated plasma-polymerized films produced by the process of the invention. In addition, the present invention is directed to the use of hydroxylated plasma-polymerized films produced by the process of the invention for enhancing the compatibility and/or implantability of biomedical implants and/or devices.
Claims14
A process for producing a hydroxylated plasma-polymerized N-vinyl-2-pyrrolidone polymer comprising the steps of:
- a) plasma-polymerizing N-vinyl-2-pyrrolidone monomers to produce an insoluble plasma-polymerized N-vinyl-2-pyrrolidone polymer;
- and
- b) reducing the carbonyl groups in the insoluble plasma-produced N-vinyl-2-pyrrolidone polymer to alcohol groups by chemical reduction using an aqueous solution of sodium borohydride.
A process for producing a hydroxylated plasma-polymerized N-vinyl-2-pyrrolidone film comprising the steps of:
- a) plasma-polymerizing N-vinyl-2-pyrrolidone monomers to produce an insoluble plasma-polymerized N-vinyl-2-pyrrolidone film;
- and
- b) immersing the insoluble plasma-polymerized N-vinyl-2-pyrrolidone film in an aqueous solution of sodium borohydride thereby reducing the carbonyl groups in the plasma-polymerized film to hydroxyl groups.
A process for producing a hydroxylated plasma-polymerized polymer comprising the steps of:
- a) utilizing a plasma polymerization process to synthesize an insoluble plasma-polymerized polymer;
- and
- b) adding the synthesized insoluble plasma-polymerized polymer an aqueous solution of a metal hydride thereby reducing the carbonyl groups in the plasma-polymerized polymers to hydroxyl groups.
A process for producing a hydroxylated plasma-polymerized N-vinyl-2pyrrolidone polymer comprising the steps of:
- a) plasma-polymerizing N-vinyl-2-pyrrolidone monomers to produce an insoluble plasma-polymerized N-vinyl-2-pyrrolidone polymer rich in carbonyl groups;
- and
- b) reducing the carbonyl groups in the insoluble plasma-produced N-vinyl-2-pyrrolidone polymer to alcohol groups by chemical reduction using an aqueous solution of sodium borohydride.
Dependencies are inferred from the claim text.